3-(2-AMINO-4-PYRIMIDINYL)-2-NAPHTHOL DERIVATIVES AS INHIBITORS OF CYCLIN DEPENDENT KINASE

摘要

PURPOSE: 3-(2-Amino-4-pyrimidinyl)-2-naphthol derivatives as inhibitors of cyclin dependent kinase are provided, thereby preventing and treating cancers associated with cyclin dependent kinase(CDK). CONSTITUTION: The 3-(2-amino-4-pyrimidinyl)-2-naphthol derivatives represented by formula (1), and pharmaceutically acceptable salts, hydrates, solvates and isomers thereof are provided, wherein R is hydrogen, hydroxy, cyano, halogen, C1-C4 alkyloxy, amino, aminosulfonyl or NH2-N-R1; and R1 is hydrogen or hydroxy. The method for preparing the 3-(2-amino-4-pyrimidinyl)-2-naphthol derivatives of formula (1) comprises reacting a compound of formula (10) with guanidine and sodium ethoxide.