发明名称 |
Human chondroitinase glycoprotein (chasegp), process for preparing the same, and pharmaceutical compositions comprising thereof |
摘要 |
The invention relates to the discovery of a novel Chondroitinase Glycoproteins (CHASEGP's), methods of manufacture, and potential uses in conditions where removal of chondroitin sulfates may be of therapeutic benefit. Chondroitinase Glycoproteins require both a substantial portion of the catalytic domain of the CHASEGP polypeptide and asparagine-linked glycosylation for optimal chondroitinase activity. The invention also includes carboxy-terminal deletion variants of CHASEGP that result in secreted variants of the protein to facilitate manufacture of a recombinant CHASEGP. Further described are suitable formulations of a substantially purified recombinant CHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.; CHASEGP is useful for the degradation of glycosaminoglycans and chondroitin sulfate proteoglycans under clinical conditions where their removal is of therapeutic value. |
申请公布号 |
AU2003297199(A8) |
申请公布日期 |
2004.07.22 |
申请号 |
AU20030297199 |
申请日期 |
2003.12.15 |
申请人 |
HALOZYME, INC. |
发明人 |
ANIRBAN KUNDU;GREGORY I. FROST;LOUIS H. BOOKBINDER |
分类号 |
C07H21/04;C12N1/20;C12N9/24;C12N9/88;C12N15/00;C12P21/00;(IPC1-7):C12P21/06;C12N9/00 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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