PHARMACEUTICAL COMPOSITIONS WITH IMPROVED DISSOLUTION
摘要
The invention relates to methods of screening mixtures containing a pharmaceutical compound and an excipient to identify properties of the pharmaceutical compound/excipient combination that retard solid-state nucleation. The invention further relates to increasing the solubility, dissolution and bioavailability of a drug with low solubility in gastric fluids conditions by combining the drug with a precipitation retardant and an optional enhancer.
申请公布号
WO2004061433(A1)
申请公布日期
2004.07.22
申请号
WO2003US41273
申请日期
2003.12.24
申请人
TRANSFORM PHARMACEUTICALS, INC.;TAWA, MARK;REMENAR, JULIUS;PETERSON, MATTHEW;ALMARSSON, ORN;GUZMAN, HECTOR;CHEN, HONGMING;OLIVEIRA, MARK
发明人
TAWA, MARK;REMENAR, JULIUS;PETERSON, MATTHEW;ALMARSSON, ORN;GUZMAN, HECTOR;CHEN, HONGMING;OLIVEIRA, MARK