COMPOUNDS HAVING BOTH ALPHA7 NACHR AGONIST AND ANTAGONIST ACTIVITY FOR TREATMENT OF CNS DISEASES

摘要

The invention discloses compounds that are selective alpha7 nAChR agonists and 5-HT3 antagonists. The compounds are useful for treating many CNS diseases. The compounds have the following Formula (I): Azabicyclo-N(H)-C(=O)-W<0 >wherein Azabicyclo is Formula (2) each R1 is independently H, alkyl, or substituted alkyl; R2 is H, alkyl, or substituted alkyl; k is 1 or 2, provided that one R2 is other than H when k is 2; R3 is H, alkyl, or an amino protecting group; W<0> is Formula (3); W is CH or N; W<1> is O, N(R4), N(C(O)R4), or S; W<2 >is O, N(R4), N(C(O)R4), or S; R is H, F, Cl, Br, I, alkyl, substituted alkyl, or alkynyl; Alkyl is both straight- and branched-chain moieties having from 1-6 carbon atoms.