| 摘要 |
The present invention relates to nucleoside disphosphate mimics and nucleoside triphosphate mimics, which contain disphosphate or triphosphate moiety mimics and optionally sugar-modifications and/or base-modifications. The nucleotide mimics of the present invention, in a form of a pharmaceutically acceptable salt, a pharmaceutically acceptable prodrug, or a pharmaceutical formulation, are useful as antiviral, antimicrobial, and anticancer agents. The present invention provides a method for the treatment of viral infections, microbial infections, and proliferative disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of the present invention optionally in combination with other pharmaceutically active agents. |
| 申请人 |
BIOTA, INC. |
发明人 |
COOK, PHILLIP, DAN;WANG, GUANGYI;BRUICE, THOMAS, W.;BOYLE, NICHOLAS, A.;LEEDS, JANET, M.;BROOKS, JENNIFER, L.;PRHAVC, MARIJA;ARIZA, MA EUGENIA;FAGAN, PATRICK, C.;JIN, YI;RAJWANSHI, VIVEK, K.;TUCKER, KATHLEEN, D. |
