发明名称 |
PROCESS FOR PREPARING ERDOSTEINE |
摘要 |
PURPOSE: A process for preparing erdosteine is provided, thereby cheaply preparing high purity of erdosteine in higher yield without side reactions under mild conditions by regulating the amount of organic bases. CONSTITUTION: The process for preparing erdosteine comprises the steps of: reacting D,L-homocysteine thiolactone chloride with bromoacetyl bromide in the presence of organic base such as triethylamine in organic solvent such as dichloromethane to prepare 3-bromoacetylamido-2-oxo-tetrahydrothiophen; and reacting 3-bromoacetylamido-2-oxo-tetrahydrothiophen with mercaptoacetic acid in the presence of organic base such as triethylamine in organic solvent such as dichloromethane, wherein a step of adding inorganic base into the reaction product of 3-bromoacetylamido-2-oxo-tetrahydrothiophen with mercaptoacetic acid and extracting erdosteine from a water-soluble layer may be further added.
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申请公布号 |
KR20040065452(A) |
申请公布日期 |
2004.07.22 |
申请号 |
KR20030002430 |
申请日期 |
2003.01.14 |
申请人 |
ENZY CHEM CO., LTD. |
发明人 |
LEE, CHEOL MIN;LEE, JONG SU;LEE, JU CHEOL;LEE, TAE SEOK;LEE, WAN HUI;YOO, CHANG HYEON;YUK, JIN SU |
分类号 |
C07D333/36;(IPC1-7):C07D333/36 |
主分类号 |
C07D333/36 |
代理机构 |
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