| 摘要 |
A compound of the formula: and its pharmaceutically effective salts, wherein R<1 >and R<2 >are independently selected from the following: (a) hydrogen, halo, R<5>-, C2-6 alkenyl, C2-6 alkynyl, hydroxy-R<5>-, R<5>-O-R<5>-, or the like; (b) Ar-, Ar-R<5>-, Ar-C2-6 alkenyl, Ar-C2-6 alkynyl, Ar-O-, Ar-O-R<5>- or the like; (c) R<5>-C(O)-, -NO2, cyano, NH2-C(O)-, R<5>-NH-C(O)-, (R<5>)2-N-C(O)-, Ar-C(O)- or the like; and (d) R<5>-C(O)-NH-, Ar-C(O)-NH- or the like; wherein Ar is optionally substitued aryl or heteroaryl such as phenyl and pyridyl; and wherein R<5 >is optionally halo-substituted C1-6 alkyl; R<3 >is selected from the following: (e) cyano, formyl, tetrazolyl, triazolyl, imidazolyl, oxazolyl, thiazolyl, R<5>-C(O)-, C2-6 alkenyl-C(O)-, C2-6 alkynyl-C(O)-, R<5>-C(O)-R<5>-, or the like; (f) R<5>-C(O)-NH-, Ar-C(O)-NH-, or the like; (g) R<5>-S-, R<5>-S(O)-, R<5>-NH-S(O)2-, or the like; and (h) Ar-C(O)-, Ar-R<5>-C(O)-, Ar-C2-6 alkenylene-C(O)- or the like; or two of R<1>, R<2 >and R<3 >together form a group of the formula -A<1>-B<1>-A<2>- or -A<1>-B<1>-A<3>-B<2>-A<2>- such as cyclic alkyl optionally substitued with oxo; R<4 >is hydrogen, halo, R<5>-C(O)- and the like; X is O, S, S(O) or S(O)2; m is 0, 1, 2, 3 or 4. The present invention also provides processes for the preparation thereof, the use thereof in treating cytokine mediated diseases and/or cell adhesion molecule (CAM) mediated diseases and pharmace
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