发明名称 |
METHODS OF IMPROVING HEALTH-RELATED QUALITY OF LIFE IN INDIVIDUALS WITH SYSTEMIC LUPUS ENRYTHEMATOSUS |
摘要 |
The invention provides methods for stabilizing or improving the health-related quality of life in individuals with SLE, and methods of selecting individuals suitable for such treatment. One method of stabilizing or improving the health-related quality of life of an individual with SLE involves the administration of an effective amount of dsDNA epitope, such as in the form of an epitope-presenting carrier or an epitope-presenting valency platform molecule like UP 394, to the individual. The invention further provides a method of stabilizing or improving the health-related quality of life of an individual with SLE involving the reduction of the level of SLE-associated antibodies in the individual, optionally through administration of a dsDNA epitope to the individual. In addition, methods of screening patients are provided. Kits useful in the methods of the invention are also provided. |
申请公布号 |
WO2004060320(A2) |
申请公布日期 |
2004.07.22 |
申请号 |
WO2003US41840 |
申请日期 |
2003.12.29 |
申请人 |
LA JOLLA PHARMACEUTICAL COMPANY;STRAND, VIBEKE;LINNIK, MATTHEW, D.;JOH, TENSHANG |
发明人 |
STRAND, VIBEKE;LINNIK, MATTHEW, D.;JOH, TENSHANG |
分类号 |
A61K31/70;A61K39/395;C12Q1/68 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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