发明名称 |
A METHOD FOR USING TETHERED BIS(POLYHYDROXYPHENYLS) AND O-ALKYL DERIVATIVES THEREOF IN TREATING INFLAMMATORY CONDITIONS OF THE CENTRAL NERVOUS SYSTEM |
摘要 |
The present invention involves the use tethered bis(polyhydroxyphenyl) compounds to slow the progression of neurological diseases in which pro-inflammatory cytokine stimulation of microglial cells is reasonably anticipated to make a significant contribution to disease pathology. Diseases for which this is the case include amyotrophic lateral sclerosis (AlS) and other motor neuron diseases (MNDs) of similar clinical presentation; Parkinson's disease (PD); Alzheimer's disease (AD); spino-bulbar atrophy; (SBA); Huntington's disease (HD); myasthenia gravis (MG); multiple sclerosis (MS); HIV-associated dementia; fronto-temporal dementia (FTD); stroke; encephalomyelitis; traumatic brain injury; age-related retinal degeneration; and other neurological diseases possessing microglial activation as a contributing pathological feature. Specific examples are presented where the tethered bis(polyhydroxyphenyl) compound is resveratrol; piceatannol; nordihydroguaiaretic acid (NDGA), curcumin, or sesamin.
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申请公布号 |
WO03103583(A8) |
申请公布日期 |
2004.07.22 |
申请号 |
WO2003US17621 |
申请日期 |
2003.06.05 |
申请人 |
OKLAHOMA MEDICAL RESEARCH FOUNDATION;HENSLEY, KENNETH, L.;FLOYD, ROBERT, A. |
发明人 |
HENSLEY, KENNETH, L.;FLOYD, ROBERT, A. |
分类号 |
C07D311/36;A61K31/05;A61K31/075;A61K31/12;A61K31/275;A61K31/352;A61K31/36;A61K31/425;A61K31/65;A61K31/69;A61K36/18;A61P9/00;A61P9/10;A61P19/02;A61P21/04;A61P25/00;A61P25/02;A61P25/14;A61P25/16;A61P25/28;A61P27/02;A61P29/00;A61P31/18;A61P35/00;C07D493/04;(IPC1-7):A61K31/047 |
主分类号 |
C07D311/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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