Fluorinating reactants and process for their preparation

摘要

Production of 1,1-difluoroalkyl amines (I) comprises reacting a carboxamide (II) with oxalyl fluoride or difluorophosgene. Production of 1,1-difluoroalkyl amines of formula (I) comprises reacting a carboxamide of formula (II) with oxalyl fluoride or difluorophosgene: R1 = H, R, (AO)nR, 3-14C aryl, 4-15C aralkyl or NR4R5; R = 1-12C alkyl; A = 2-12C alkylene; n = 1-5; R4, R5 = 1-8C alkyl or NR4R5 is a 4- to 7-membered ring with 3-16 C atoms; R2, R3 = R, 3-14C aryl or 4-15C aralkyl or NR2R3 is a ring with 3-16 C atoms; alternatively R1 forms a 3-16C ring with R2 and/or R3.