摘要 |
A 5-membered cyclic compound of the formula: <CHEM> wherein X is oxygen or sulfur, R<1> is hydrogen, substituted or unsubstituted alkyl, etc., R<2> is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, etc., Y<1> is a direct bond, substituted or unsubstituted alkylene, -CO(CH2)n-, etc., the wavy line means (E)-configuration or (Z)-configuration, R<3> is substituted or unsubstituted aryl, etc., Y<2> is substituted or unsubstituted alkylene, etc., R<4> is hydrogen, substituted or unsubstituted alkanoyl, substituted or unsubstituted alkyl, etc., R<5> is hydrogen, etc., or a salt thereof, these compound being able to inhibit infiltration of leukocytes such as eosinophils and lymphocytes, by which being useful for the treatment of various kinds of inflammation. |
申请人 |
SUMITOMO PHARMACEUTICALS COMPANY, LIMITED |
发明人 |
FUJIWARA, NORIO;FUJITA, HITOSHI;ANTOKU, FUJIO;SUGASAWA, TOSHINARI;KAWAKAMI, HAJIME |