| 摘要 |
The present invention refers to a pharmaceutical composition comprising a therapeutically effective amount of a compound of the formula Ia: <CHEM> wherein R1 is -alkyl-NR3-CO-O-R4 or -alkenyl-NR3-CO-O-R4; R4 is aryl, heteroaryl, heterocyclyl, alkyl or alkenyl, each of which may be unsubstituted or substituted by one or more substituents selected from the group consisting of: -alkyl; -alkenyl; -aryl; -heteroaryl; -heterocyclyl; -substituted aryl; -substituted heteroaryl; -substituted heterocyclyl; -O-alkyl; -O-(alkyl)0-1-aryl; -O-(alkyl)0-1-substituted aryl; -O-(alkyl)0-1-heteroaryl; -O-(alkyl)0-1-substituted heteroaryl; -O-(alkyl)0-1-heterocyclyl; -O-(alkyl)0-1-substituted heterocyclyl; -COOH; -CO-O-alkyl; -CO-alkyl; -S(O)0-2-alkyl; -S(O)0-2-(alkyl)0-1-aryl; -S(O)0-2-(alkyl)0-1-substituted aryl; -S(O)0-2-(alkyl)0-1-heteroaryl; -S(O)0-2-(alkyl)0-1-substituted heteroaryl; -S(O)0-2-(alkyl)0-1-heterocyclyl; -S(O)0-2-(alkyl)0-1-substituted heterocyclyl; -(alkyl)0-1-NR3R3; -(alkyl)0-1-NR3-CO-O-alkyl; -(alkyl)0-1-NR3-CO-alkyl; -(alkyl)0-1-NR3-CO-aryl; -(alkyl)0-1-NR3-CO-substituted aryl; -(alkyl)0-1-NR3-CO-heteroaryl; -(alkyl)0-1-NR3-CO-substituted heteroaryl; -N3; -halogen; -haloalkyl; -haloalkoxy; -CO-haloalkoxy; -NO2; -CN; -OH; -SH; and, in the case of alkyl, alkenyl, or heterocyclyl, oxo; R2 is selected from the group consisting of: -hydrogen; -alkyl; -alkenyl; -aryl; -substituted aryl; -heteroaryl; -substituted heteroaryl; -alkyl-O-alkyl; -alkyl-O-alkenyl; and -alkyl or alkenyl substituted by one or more substituents selected from the group consisting of: -OH; -halogen; -N(R3)2; -CO-N(R3)2; -CO-C1-10 alkyl; -CO-O-C1-10 alkyl; -N3; -aryl; -substituted aryl; -heteroaryl; -substituted heteroaryl; -heterocyclyl; -substituted heterocyclyl; -CO-aryl; -CO-(substituted aryl); -CO-heteroaryl; and -CO-(substituted heteroaryl); each R3 is independently selected from the group consisting of hydrogen and C1-10 alkyl; n is 0 to 4 and each R present is independently selected from the group consisting of C1-10 alkyl, C1-10 alkoxy, halogen and trifluoromethyl, or a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable carrier.
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