HUMAN MONOCLONAL ANTIBODY AGAINST HEPATITIS B VIRUS SURFACE ANTIGEN (HBVSAG)

摘要

Disclosed is a hybridoma cell line which produces human antibodies capable o f binding to the hepatitis B virus surface antigen (HBVsAg), as well as antibodies produced by the cell line. Also disclosed ar e various uses of said antibodies in the prevention and treatment of HBV infection. Peripheral blood lymphocytes obtained from human donors having a high titer of anti HBVsAg antibodies are activated in vitro with pokeweed mitogen and then fused with heteromyelo ma cells to generate hybridomas secreting human antibodies having a high affinity and specificity to HBVsAg.