| 摘要 |
The compounds represented by the formulae (I) wherein X is selected from the group consisting of: O, S, N-R<1>, and CHR<1>; Y and Y' is individually selected from H, OR<1>, NR<1>R<2>, and N3 Z and Z' is individually selected from II, OR<1>, and NR<1>R<2 >R=II, formula (II), formula (III), or formula (III), R<1 >and R<2 >is selected from H, alkyl, acyl, aryl which may be substituted or unsubstituted, R<3 >is selected from H, alkyl, alkenyl, alkynyl, aryl, acyloxyalkyl, and pivaloyloxyalkyl, B is selected from 5 or 6-substituted uracil or cytosine, pseudouracil, N-substituted pseudouracil, 2-thiouracil, 2-thiocytosine, 5- or 6-substituted 2-thiouracil and 2-thiocytosine, 6-azauracil, 5-azacytosine, 8-azapurines, and 7-aza-8-deazapurines. Substitutions may be halosubstituted alkyl, halosubstituted alkenyl, halosubstituted alkynyl, halosubstituted aryl, alkylthio, or NR<1>R<2>. When Z and Z' are H and Y or Y' is OH then B is not 5-methyl uracil or cytosine; and pharmaceutically acceptable salts thereof, mono, di or triphosphate and prodrugs thereof.
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