METHOD FOR PROVIDING NATURAL THERAPEUTIC AGENTS WITH HIGH THERAPEUTIC INDEX

摘要

Methods for identifying and providing new therapeutic agent(s) by selecting at least one polypeptide encoded by a natural allelic variant of one preselected gene having a therapeutic potential; determining the therapeutic index of the selected polypeptide(s) and retaining as therapeutic agent(s) those polypeptide(s) whose therapeutic index is higher than that of a reference agent. The therapeutic indices of antiviral, anti-proliferative and immunomodulatory activities as well as toxicity are determined for members of the IFNalpha gene family.