发明名称 |
Process improvements in steroid chemistry |
摘要 |
Steroids containing a cyclohexene moiety are efficiently oxidized to the corresponding alpha,beta-unsaturated ketone using copper iodide and t-butyl hydroperoxide. A steroid compound containing the alpha,beta-unsaturated ketone structure is efficiently converted to the corresponding vicinal diol using a hydroborating reagent followed by oxidative workup, e.g., borane followed by sodium perborate. Benzoyl and substituted benzoyls are superior protecting groups for hydroxyl groups present in the compounds.
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申请公布号 |
US2004138486(A1) |
申请公布日期 |
2004.07.15 |
申请号 |
US20030744857 |
申请日期 |
2003.12.22 |
申请人 |
INFLAZYME PHARMACEUTICALS LTD. |
发明人 |
BURGOYNE DAVID L.;JI GUEIJUN;KELLEHER EUGENE W.;PASCHALIDES NICHOLAS D.;RAMACHANDRAN KISHORE;SHEN YAPING;ZHOU YUANLIN |
分类号 |
A61K31/56;C07B53/00;C07J1/00;C07J11/00;C07J21/00;C07J31/00;C07J41/00;C07J53/00;(IPC1-7):C07J1/00 |
主分类号 |
A61K31/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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