发明名称 |
Mesenchymal stem cells as a vehicle for ion channel transfer in syncytial structures |
摘要 |
This invention provides a composition for delivery of a gene to a syncytial structure comprising stem cells incorporated with the gene. This invention also provides a composition for ion channel transfer which comprises stem cells incorporated with a compound in an amount sufficient to create ion channels. This invention also provides for a method of expressing a functional gene product in a syncytial structure comprising administering a composition, comprising stem cells that have been incorporated with a gene, to the syncytial structure. This invention further provides a method of expressing a functional ion channel in a syncytial structure comprising administering a composition, comprising stem cells that have been incorporated with a compound in an amount sufficient to create ion channels, to the syncytial structure. This invention also provides a composition for delivery of small molecules comprising stem cells incorporated with the small molecules or genes encoding the small molecules.
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申请公布号 |
US2004137621(A1) |
申请公布日期 |
2004.07.15 |
申请号 |
US20030342506 |
申请日期 |
2003.01.15 |
申请人 |
ROSEN MICHAEL R.;ROBINSON RICHARD B.;COHEN IRA S.;BRINK PETER |
发明人 |
ROSEN MICHAEL R.;ROBINSON RICHARD B.;COHEN IRA S.;BRINK PETER |
分类号 |
A61K48/00;C07K14/705;C12N5/0775;(IPC1-7):C12N15/87;C12N5/08 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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