METHOD FOR CYTOPROTECTION THROUGH MDM2 AND HDM2 INHIBITION
摘要
The present invention is directed to a method of protecting one or more cells from programmed cytotoxic cell death by contacting the cells with a cytoprotective amount of an MDM2 and/or HDM2 inhibitor. The cytoprotective amount of inhibitor is typically used as a pulsed administration. Useful inhibitors include a class of 1,4-benzodiazepines, which act as inhibitors of MDM2-p53 interactions. The method of the invention can be employed as an adjunct to chemotherapy or radiation therapy. In addition, the methods of the invention can be employed to treat a disease or condition that involves excessive cell death.
申请公布号
WO03095625(A3)
申请公布日期
2004.07.15
申请号
WO2003US14923
申请日期
2003.05.13
申请人
3-DIMENSIONAL PHARMACEUTICALS, INC.;KOBLISH, HOLLY, K.;MANTHEY, CARL, L.;MOLLOY, CHRISTOPHER, J.
发明人
KOBLISH, HOLLY, K.;MANTHEY, CARL, L.;MOLLOY, CHRISTOPHER, J.