TRIPTOLIDE DERIVATIVES AND THEIR USE

摘要

Triptolide derivatives of Formula (I), their pharmaceutically receptable salts and optical isomers, Formula (I), (wherein, C5 and C6 connect with each other by a C-C single bond or double bond; when C5 and C6 are connected with C-C single bond, X and Y represents independently hydrogen, oxygen, hydroxy, halogen, lower alkyloxy, lower alkylamino, mercapto, lower alkylthio, the group of formula -OCOR, -OSO2OR or -OPO(OH)2, each of which is attached to C5 and C6, R represents -(CH2)nCO2Na, -(CO2)nCO2K, or -(CH2)nCH3, wherein n = 1-6; Z represents hydrogen, oxygen, hydroxy, halogen, lower alkyloxy, lower alkylamino, mercapto, lower alkylthio, the group of formula -OCOR, -OSO2OR or -OPO(OH)2, each of which is linked at C14-position, R represents -(CH2)nCO2Na, -(CO2)nCO2K, or -(CH2)nCH3, wherein n = 1-6; wherein, the "__" linked with X, Y, and Z represents "(a) " or "(b)" , provided that X and Y cannot both be hydrogen atom at the same time), the methods for preparing them and their use as antiphlogistic agent, immunosuppressive agent or therapeutic agent for other related diseases.