CRYSTALLINE LIVER X RECEPTOR BETA PROTEIN

摘要

The present invention is in the fields of biotechnology, protein purificatio n and crystallization, x-ray diffraction analysis, three-dimensional computer molecular modelling and rational drug design. The invention is directed to t he Liver X receptor and ligands for this receptor, and in particular to crystalline Liver X receptor beta (LXR.beta.) and to methods of identifying ligands utilizing LXR.beta., as well as to compounds, compositions and metho ds for selecting, making, and using therapeutic or diagnostic agents having LXR.beta. modulating or binding activity.