Histamine receptor antagonists

摘要

The present invention provides a combination of (a) a histamine H1 receptor antagonist and (b) an antagonist that is at least 10-fold selective for the histamine H4 receptor as compared to the histamine H3 receptor; and an antagonist that is at least 10-fold selective for the histamine H4 receptor as compared to the histamine H3 receptor: and compositions and uses thereof.