摘要 |
The invention concerns screening molecules with anti-prion activity. More particularly, it concerns kits for screening molecules with anti-prion activity characterized in that they comprise in combination a [PSI+], phenotype yeast, an antibiogram and an agent for purifying prions at sub-efficient doses, said yeast including the ade1-14 allele of the ADE1 gene and an inactivated ERG6 gene, the screening methods, and a family of molecules with anti-prion activity isolated by the inventive screen. The invention is applicable to anti-prion agents for producing medicines in particular for treating neurodegenerative diseases involving protein aggregates. |
申请人 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);UNIVERSITE VICTOR SEGALEN;UNIVERSITE DE POITIERS;BLONDEL, MARC;BACH, STEPHANE;CULLIN, CHRISTOPHE;TALAREK, NICOLAS;VIERFOND, JEAN-MICHEL;METTEY, YVETTE |
发明人 |
BLONDEL, MARC;BACH, STEPHANE;CULLIN, CHRISTOPHE;TALAREK, NICOLAS;VIERFOND, JEAN-MICHEL;METTEY, YVETTE |