| 摘要 |
The first element of the invention is a moldable, resorbable composite bone graft consisting of calcium phosphate cement, an aqueous medium, and biodegradable polymer microspheres or other porogens. The composite bone graft is osteoconductive, i.e., the degradation of the microspheres or other porogens leads to macropores that facilitate the growth of osteoblasts into the bone grafts, and the degradation rate of microspheres or other porogens can be controlled such that the formation of macrpores is in tune with the ingrowth of osteoblasts. Additionally, growth factors or other bioactive agents can be incorporated into the moldable, resorbable composite bone grafts. The growth factors can be added to the liquid component of the bone grafts or, can be encapsulated in a biodegradable porogen and then added to the solid component of the bone grafts (or both). The release patterns of the growth factors are modulated by varying the volume fraction and the dissolution rate of the pore-forming particulates, which are biodegradable polymer microspheres or other watersoluble particles.
|
