1-ALKYL-3-AMINOINDAZOLES

摘要

Methods of making 1-alkylindazoles are described. The methods involve reacti ng a 2-alkylaminobenzonitrile with a nitrosating agent followed by reduction- cyclization of the resulting nitrosamine to form a 1-alkyl-3-aminoindazole. The 1-alkyl-3-aminoindazole can be deaminated to form a 1-alkylindazole whic h ultimately can be used to form desired indazoles which are preferably pharmaceutically active products. The process of the present invention furth er permits the formation of enantiomerically enriched or pure indazoles such as aminoalkyl indazoles.