| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for efficiently producing in high purity 7α-hydroxy-pregna-4-en-3-one-20-carbaldehyde useful as an intermediate for synthesizing pharmaceuticals including squalamine. SOLUTION: This method for producing 7α-hydroxy-pregna-4-en-3-one-20-carbaldehyde comprises culturing bacteria belonging to the genus Alcaligenes having the ability to produce 7α-hydroxy-pregna-4-en-3-one-20-carbaldehyde from 3α,7α-dihydroxy-5β-cholanic acid and/or a salt thereof as substrate in a medium containing 3α,7α-dihydroxy-5β-cholanic acid and/or a salt thereof. COPYRIGHT: (C)2004,JPO&NCIPI
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