KETONE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX

摘要

This invention relates to a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligan d binding domain; a transactivation domain; and a ligand is contacted with a D NA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of t he DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene. The ligands comprise a cla ss of ketones.