SPIROCYCLIC PIPERIDINES AS MCH1 ANTAGONISTS AND USES THEREOF

摘要

This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. Thi s invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a proce ss for making a pharmaceutical composition comprising combining a therapeutical ly effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of reducing the bo dy mass of a subject which comprises administering to the subject an amount of a compound of the invention effective to reduce the body mass of the subject. This invention further provides a method of treating a subject suffering fro m depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject=s depression and/or anxiety. This invention further provides a method of treating a subject suffering from a urinary disorder.