| 摘要 |
Proteins which is involved in T cell activation, which are used for diagnosing, treating or preventing diseases associated with disorder of T cells, are provided. Using reporter plasmids pNFkappaB-Luc or pNFAT-Luc, cDNAs encoding proteins having a function of activating NFkappaB or NFAT in T cells were cloned from the cDNA library constructed from human peripheral blood monocyte (PBMC), and the DNA sequence and the deduced amino acid sequence are determined. The protein, the DNA encoding the protein, a recombinant vector containing the DNA, and a transformant containing the recombinant vector are used for screening a substance inhibiting or promoting T cell activation. |
