| 摘要 |
A composition containing an expression vector which encodes an antigen recognized by CD4+ helper T lymphocyte and an antigen recognized by CD8+ cytotoxic T lymphocyte (CTL) (in particular, a tumor-specific antigen, a tum or- associated antigen or a cell-associated antigen), preferably containing an expression vector encoding interferon-gamma. Specific examples of the antige n recognized by CD4+ helper T lymphocyte include cancer/testis antigens such a s NY-ESO-1, while specific examples of the antigen recognized by CD8+ cytotoxi c T lymphocyte (CTL) (in particular, a tumor-specific antigen, a tumor- associated antigen or a cell-associated antigen) include HER-2/neu and cancer/testis antigens such as NY-ESO-1, MAGE and SAGE.
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