发明名称 |
PREPARATION OF LACTAMS FROM ALIPHATIC ALPHA,OMEGA-DINITRILES |
摘要 |
A process for the preparation of five-membered or six-membered ring lactams from aliphatic alpha , omega -dinitriles has been developed. In the process an aliphatic alpha , omega -dinitrile is first converted to an ammonium salt of an omega -nitrilecarboxylic acid in aqueous solution using a catalyst having an aliphatic nitrilase (EC 3.5.5.7) activity, or a combination of nitrile hydratase (EC 4.2.1.84) and amidase (EC 3.5.1.4) activities. The ammonium salt of the omega -nitrilecarboxylic acid is then converted directly to the corresponding lactam by hydrogenation in aqueous solution, without isolation of the intermediate omega -nitrilecarboxylic acid or omega -aminocarboxylic acid. When the aliphatic alpha , omega -dinitrile is also unsymmetrically substituted at the alpha -carbon atom, the nitrilase produces the omega -nitrilecarboxylic acid ammonium salt resulting from hydrolysis of the omega -nitrile group with greater than 98% regioselectivity, thereby producing only one of the two possible lactam products during the subsequent hydrogenation. A heat-treatment process to select for desirable regioselective nitrilase or nitrile hydratase activities while destroying undesirable activities is also provided. |
申请公布号 |
EP0901468(B1) |
申请公布日期 |
2004.07.14 |
申请号 |
EP19970929676 |
申请日期 |
1997.05.07 |
申请人 |
E.I. DU PONT DE NEMOURS AND COMPANY |
发明人 |
DI COSIMO, ROBERT;FALLON, ROBERT, DONALD;GAVAGAN, JOHN, EDWARD;HERKES, FRANK, EDWARD |
分类号 |
C07C255/19;C07C255/23;C07D201/08;C07D207/26;C07D211/76;C07D223/10;C12N9/78;C12N9/88;C12P13/00;C12P17/10 |
主分类号 |
C07C255/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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