Controlled release, multiple unit drug delivery systems

摘要

The invention relates to controlled release multiple unit system of carvedilol for oral administration, and methods of preparing the system, which can be easily compressed into tablets or filled into capsules or sachets without affecting the desired release characteristics of the pharmaceutical active ingredient incorporated within the system. The multiple unit system includes multiple units. Each unit includes at least one core and having an outer surface; a first coating layer surrounding at least a portion of the outer surface of the core and having an outer surface, the coating layer including carvedilol; a second rate controlling coating layer surrounding at least a portion of the outer surface of the first coating layer and having an outer surface, the coating layer including one or more sustained release polymers and one or more enteric polymers. The multiple unit system may optionally contain a seal coat between inert core and carvedilol layer, or between carvedilol layer and rate controlling polymer layer. The units are finally compressed into tablet or filled into capsule/sachet.