USE OF CARDIOTROPHIN IN HEPATIC DISEASES

摘要

Use of cardiotrophin-1 (CT-1), its active fractions, polypeptides with CT-1 activity or nucleic acid encoding any of these (collectively referred to as (A)), to prepare a composition for stimulating regeneration of the liver or as hepatoprotectant, is new. An INDEPENDENT CLAIN is also included for culturing hepatocytes comprising adding (A) to the culture medium. ACTIVITY : Hepatotropic; Antiinflammatory; Virucide; Cytostatic. MECHANISM OF ACTION : Gene Therapy. CT-1 may function as a cytokine that regulates apoptosis of hepatocytes and stimulates their proliferation, especially by inducing both the JAK/STAT proliferation/differentiation system and the PI-3K/STAT survival pathway (disclosed).