| 摘要 |
This invention relates to N-acylamino aryl derivatives of the formulawhereR<1>, R<21>, R<22>, R<23>, R<24>, R<3>, R<4>, R<5 >R<6>, R<7>, R<8>, R, andn are as defined herein and whereX is -CHRO, -OCHR-, -CH2S-, -SCH2-, -CH2CH2-, -CH=CH- or -C=C-.The compounds of the invention are selective monoamine oxidase B inhibitors, and they are therefore useful in the treatment of diseases mediated by monoamine oxidase B, for example, for the treatment of Alzheimer's disease or senile dementia.
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