Polynucleotides encoding polymorphic human GABAA receptor alpha-6 subunit

摘要

Compositions and methods based on a polymorphism in the gene encoding the alpha6 subunit of the human GABAA neurotransmitter receptor are disclosed. This polymorphism results in the substitution of a serine residue for a proline residue ordinarily present at amino acid position 385 of the alpha6 polypeptide sequence. Significantly, the polymorphism was associated with decreased sensitivity to ethanol and benzodiazepine drugs.