| 发明名称 |
METHOD FOR INHIBITION OF RAF KINASE-MEDIATED GROWTH OF TUMOR CELLS, HETEROCYCLIC UREA DERIVATIVES (VARIANTS), PHARMACEUTICAL COMPOSITION (VARIANTS) |
| 摘要 |
FIELD: organic chemistry, medicine, biochemistry, pharmacy. ^ SUBSTANCE: invention relates to a method for inhibition of RAF kinase-mediated growth of tumor cells that involves administration of derivatives of substituted urea of the formula (I): ^ ^ heterocyclic derivatives of urea of the formula (I) and pharmaceutical composition comprising derivatives of urea of the formula (I). Invention provides enhanced effectiveness of inhibition. ^ EFFECT: improved inhibition method, valuable medicinal properties of compounds. ^ 79 cl, 5 tbl, 58 ex |
| 申请公布号 |
RU2232015(C2) |
申请公布日期 |
2004.07.10 |
| 申请号 |
RU20000120184 |
申请日期 |
1998.12.22 |
| 申请人 |
|
发明人 |
VUD DZHIL EH.;DZHONSON DZHEFRI;DJUMA ZHAK;KAJRE JUDEHJ;LI UEHNDI;LOUINGER TIMOTI BRUNO;PAUL'SEN KHOL'GER;REDMEHN ANIKO;RENIK DZHOUEHL;RIDL' BERND;SIBLI ROBERT;SKOTT UIL'JAM DZH.;SMIT RODZHER EH.;KHATOUM-MOKDAD KHOLIJA |
| 分类号 |
A61K31/17;A61K31/34;A61K31/381;A61K31/41;A61K31/415;A61K31/42;A61K31/422;A61K31/4245;A61K31/425;A61K31/428;A61K31/4427;A61K31/4433;A61K31/4436;A61K31/4439;A61K31/444;A61K31/4709;A61K31/496;A61K31/506;A61K31/5377;A61P35/00;A61P43/00;C07C275/26;C07C275/28;C07D231/40;C07D257/06;C07D261/14;C07D271/10;C07D271/113;C07D277/28;C07D285/12;C07D285/135;C07D333/36;C07D401/12;C07D409/12;C07D413/12;C07D413/14;C07D417/12;C07D521/00 |
主分类号 |
A61K31/17 |
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