Beta secretase transgenic organisms and methods of use thereof

摘要

The invention provides transgenic non-human animals, such as transgenic rodents and transgenic non-human mammalian cells harboring a transgene which eliminates the expression of a beta-secretase BACE1. Also provided are methods of diagnosing neurodegenerative diseases including Alzheimer's Disease as well as methods of identifying agents which modulate or treat Alzheimer's Disease and related pathology.