| 摘要 |
A compound according to formula (I) wherein: {circle over (C is a phenyl ring, a C4 to C9 heteroaromatic compound containing one or more heteroatoms, or a naphthalenyl, 5,6,7,8-tetrahydronaphthalenyl or biphenyl group; R<1>, R<2 >and R<3 >each independently represent a hydrogen or halogen atom, or a hydroxy group, or a phenyl, -OR<4>, -SR<4>, -NR<4>R<5>, -NHCOR<4>, -CONR<4>R<5>, -CN, -NO2, -COOR<4 >or -CF3 group, or a straight or branched lower alkyl group which may optionally be substituted, for example, with a hydroxy or alcoxy group, wherein R<4 >and R<5 >each independently represent a hydrogen atom, straight or branched lower alkyl group, or together form an alicyclic ring; or R<1 >and R<2 >together form an aromatic, alicyclic or heterocyclic ring; n is an integer from 0 to 4; A represents a -CH2-, -CH=CR<6>, -CR<6>=CH-, -CR<6>R<7>-, -CO-, -O-, -S-, -S(O)-, SO2 or -NR<6>- group, wherein R<6 >and R<7 >each independently represent a hydrogen atom, straight or branched lower alkyl group, or R<6 >and R<7 >together form an alicyclic ring; m is an integer from 0 to 8; provided that when m=0, A is not -CH2-; p is an integer from 1 to 2 and the substitution in the azoniabicyclic ring may be in the 2, 3 or 4 position including all possible configurations of the asymmetric carbons; B represents a group of formula i) or ii): wherein R<10 >represents a hydrogen atom, a hydroxy or methyl group; and R<8 >and R<9 >each independently represents wherein R<11 >represents a hydrogen or halogen atom, or a straight or branched lower alkyl group and Q represents a single bond, -CH2-, -CH2-CH2-, -O-, -O-CH2-, -S-, -S-CH2- or -CH=CH-, and when i) or ii) contain a chiral centre they may represent either configuration; X represents a pharmaceutically acceptable anion of a mono or polyvalent acid, which shows high affinity for muscarinic M3 </subs
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