发明名称 |
Fas peptide mimetics and uses thereof |
摘要 |
Exocyclic peptide mimetics that disable Fas were developed. A three dimensional model of the Fas receptor-ligand complex was constructed and structurally predicted regions of the receptor that were relevant to binding ligand were used to create constrained peptide mimetics. Exocyclic anti-Fas peptide mimetics were identified that block Fas receptor-ligand interactions, and modulate Fas biological activity both in vitro and in vivo. The mimetics are useful, e.g., for treating Fas-related pathologies.
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申请公布号 |
US2004132641(A1) |
申请公布日期 |
2004.07.08 |
申请号 |
US20040445399 |
申请日期 |
2004.02.18 |
申请人 |
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
GREENE MARK I.;MURALI RAMACHANDRAN;HASEGAWA AKIHIRO |
分类号 |
A61K38/00;A61P1/16;A61P13/12;A61P19/02;A61P25/00;A61P27/02;A61P29/00;A61P31/18;A61P37/02;A61P37/06;A61P39/00;C07K14/525;C07K14/705;(IPC1-7):A61K38/12;C07K7/64 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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