发明名称 |
METHOD OF TREATING LEUKEMIA WITH A COMBINATION OF SUBEROYLANILIDE HYDROMAXIC ACID AND IMATINIB MESYLATE |
摘要 |
A method for inducing apoptosis, or increasing the rate or extent of apoptosis, in target cells. The method comprises the steps of contacting the cancer cells with an apoptosis-inducing amount of a tyrosine kinase inhibitor, imatinib mesylate, and a histone deacetylase inhibitor, Suberoylanilide Hydromaxic Acid (SAHA). The method is applicable to ameliorating the resistance of the accelerated and blast phases of CML (CML-BC) to imatinib mesylate. |
申请公布号 |
WO2004026234(A3) |
申请公布日期 |
2004.07.08 |
申请号 |
WO2003US28964 |
申请日期 |
2003.09.19 |
申请人 |
UNIVERSITY OF SOUTH FLORIDA |
发明人 |
BHALLA, KAPIL, N.;NIMMANAPALLI, RAMEDEVI |
分类号 |
A61K45/06 |
主分类号 |
A61K45/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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