| 摘要 |
The present invention relates to the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein (A) one of X and Y is S, a nd the other is N; or one of X and Y is NH or N-R5, and the other is C-R6; "a" is a single bond; "b", "c", "d", "e" and "f' are single or double bonds so as t o form a heteroaryl ring; R1 is is R7 with the proviso that R1 is other than H or Me; or (B) one of X and Y is S, and the other is NH or N-R5; "a" and "d" are each double bonds; "b", "c", "e" and "f' are each single bonds; R1 is ox o; and R2, R3, R4, R5, and R6 are each independently H or R7; R7 is a group (CH2)n-R8, wherein n is 0, 1, 2, 3 or 4 and wherein R8is selected from alkyl , aryl, heteroaryl, heterocycloalkyl, F, Cl, Br, I, CF3, NO2, CN, OH, O-alkyl, O- aryl, 0~- heteroaryl, 0-heterocycloalkyl, CO-alkyl, CO-aryl, CO-heteroaryl, CO- heterocycloalkyl, COO-alkyl, NH2, NH-alkyl, NH-aryl, N(alkyl)2, NH-heteroary l, NH-heterocycloalkyl, COOH, CONH2, CONH-alkyl, CON(alkyl)2, CONH-aryl, CONH- heteroaryl, CONH~heterocycloalkyl, SO3H, S02-alkyl, SO2-aryl, S02-heteroaryl , SO2-heterocycloalkyl, SO2NH2, SO2NH-alkyl, SO2N(alkyl)2, SO2NH-aryl, SO2NH- heteroaryl, or SO2NH~heterocycloalkyl, wherein said alkyl, aryl, heteroaryl, and heterocycloalkyl groups are optionally substituted with one or more grou ps selected from halogeno, NO2, OH, 0~methyl, NH2, COOH, CONH2 and CF3; in the preparation of a medicament for treating diabetes. The compounds of the invention also have applications in the treatment of CNS disorders, alopecia , cardiovascular disorders and stroke.
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