| 发明名称 |
CHIMERIC AND HUMANIZED ANTIBODIES TO .ALPHA.5.BETA.1 INTEGRIN THAT MODULATE ANGIOGENESIS |
| 摘要 |
<p>The present invention provides chimeric and humanized antibodies that specifically recognize .alpha.5.beta.1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provide d are methods of determining therapeutically acceptable doses of the antibodie s and pharmaceutical compositions including the same.</p> |
| 申请公布号 |
CA2507099(A1) |
申请公布日期 |
2004.07.08 |
| 申请号 |
CA20032507099 |
申请日期 |
2003.11.26 |
| 申请人 |
PROTEIN DESIGN LABS, INC. |
发明人 |
RAMAKRISHNAN, VANITHA;JEFFRY, URSULA;POWERS, DAVID;JOHNSON, DALE E. |
| 分类号 |
C07K16/28;C07K16/42;(IPC1-7):C12N15/62;C07K1/22;C12N15/13;A61K39/395;C07K16/46;G01N33/50 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
