| 摘要 |
Compounds represented by formula 1: wherein R<1 >is H, halogen, (C1-4)alkyl, O(C1-4)alkyl, and haloalkyl; R<2 >is H or methyl; R<3 >is H or (C1-4)alkyl; R<4 >is H or (C1-4)alkyl; R<5 >is (C1-4)alkyl, (C1-4)alkyl(C3-7)cyclo-alkyl or (C3-7)cycloalkyl; and W is a fused phenyl-5 or 6-membered heterocycle having one or two heteroatoms selected from N or S; or W is phenyl, 1,1'-biphenyl, 2,3-dihydro-1H-indene, 1,2,3,4-tetrahydronaphthyl, or naphthyl; said W being optionally substituted with (C1-4)alkyl, which in turn can be optionally substituted with a carboxy or (C1-4)alkoxycarbonyl, or a salt or ester thereof. The compounds have inhibitory activity against Wild Type, single and double mutant strains of HIV.
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