CHIMERIC AND HUMANIZED ANTIBODIES TO alpha5beta1 INTEGRIN THAT MODULATE ANGIOGENESIS
摘要
The present invention provides chimeric and humanized antibodies that specifically recognize alpha5beta1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.
申请公布号
WO2004056308(A2)
申请公布日期
2004.07.08
申请号
WO2003US38172
申请日期
2003.11.26
申请人
PROTEIN DESIGN LABS, INC.;RAMAKRISHNAN, VANITHA;POWERS, DAVID;JOHNSON, DALE E.,;JEFFRY, URSULA