发明名称 |
PROCESS FOR THE RECYCLING OF SOLID PHASE BONDED CTC-RESIN |
摘要 |
The present invention relates to a recycling process for the preparation of solid phase bonded 2-chlorotrityl chloride (2-CTC resin) useful for solid phase peptide synthesis. Specifically what is claimed is a process for the preparation of solid phase bonded 2-chlorotrityl chloride (2-CTC resin) of formula I, wherein Ps is a polymeric support and n has the following meaning : 1 >= n> 0 comprising the reaction of solid phase bonded 2-chlorotrityl of formula II, wherein R is OH or/and OC1-4-alkyl or/and NR'R" wherein R' and R " independently of each other represent C1-4-alkyl, or R' and R" together with the nitrogen to which they are bonded represent a 5 to 8 membered heterocycl ic radical in the presence of a chlorinating agent and an organic solvent.</SDO AB>
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申请公布号 |
CA2506533(A1) |
申请公布日期 |
2004.07.08 |
申请号 |
CA20032506533 |
申请日期 |
2003.12.12 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
BARLOS, KLEOMENIS;KNIPP, BERNHARD |
分类号 |
C08F8/20;(IPC1-7):C08F8/20 |
主分类号 |
C08F8/20 |
代理机构 |
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