DICATIONIC 2,5-DIARYLFURAN AZA-ANALOGS AS ANTI-PROTOZOAN AGENTS

摘要

A compound of Formula (I): wherein: X is selected from the group consisting of O, S, and NR <17, >where R<17> is hydrogen or lower alkyl; C<1>, C<2>, A, and Y are CH, N, NR <17, >O, or S, wherein C<1> and C<2> are the same or different; D<1>, D<2>, B, and Z are CH, N, or NR <17 >wherein D<1> and D<2> are the same or different; provided that B, Z, or both B and Z are not present when A, Y, or both A and Y are O, S, or NR<17>; R<13>,R<14>, R<15>, R<16>, R<1> and R<8> are selected from the group consisting of H, lower alkyl, halogen, alkoxyl, aryloxyl, aralkoxy and hydroxyl; R<3> and R<6> are each independently selected from the group consisting of H, hydroxy, lower alkyl, cycloalkyl, aryl, aralkyl, alkoxyl, hydroxycycloalkyl, alkoxycycloalkyl, hydroxyalkyl, aminoalkyl, acyloxy, acetoxy, and alkylaminoalkyl; and R<2>, R<4>, R<5> and R<7> are each independently selected from the group consisting of H, lower alkyl, alkoxyalkyl, cycloalkyl, aryl, aralkyl, hydroxyalkyl, aminoalkyl, and alkylaminoalkyl, or R<2> and R<4> together or R<5> and R<7> together represent a C2 to C10 alkyl, hydroxyalkyl, or alkylene, or R<3> and R<4> together or R<6> and R<7> together are: wherein n is a number from 1 to 3, and R<9> is H or-CONHR<10>NR<11>R<12>, wherein R<10>, is lower alkyl and R<11> and R<12 >are each independently selected from the group consisting of H and lower alkyl.