摘要 |
The subject invention provides compounds having the structure (I): wherein R1 is present or absent, and when present is H, C1-C6alkyl, C1-C6 alkynyl, - (CH2)yS (CH2 )xCH3, C1-C6 aminoalkyl, C1-C6 hydroxyalkyl or -(CH2)nC(=0) (C6H4) (CH2)R2; R2 is H or C1-C4 alkyl; R3 is H or C1-C4 alkyl; R4 is present or absent, and when present is H, C1-C6 alkyl, C1-C6 alkynyl, - (CH2) yS (CH2) xCH3 , C1-C6 aminoalkyl, C1-C6 hydroxyalkyl or -(CH2) nC (=O) (C6H4) (CH2) R2; wherein n is an integer from 1-6; wherein x is 0 or an integer from 1-5 and y is an integer from 1-5, such that x+y<6; AT LEAST ONE OF R1 or R4 is present; the dashed line represents a bond between one of the nitrogen atoms and the intervening carbon atom; and any compound is charged when both R1 and R4 are present, or any specific enantiomer thereof or any pharmaceutically acceptable salt thereof, and a method for treating a neurologic disorder or multiple sclerosis by administering a therapeutically effective amount any of the compounds.. |
申请人 |
TEVA PHARMACEUTICAL INDUSTRIES, LTD.;TEVA PHARMACEUTICAL USA, INC. |
发明人 |
STERLING, JEFFREY;HAYARDENY, LIAT;FLAB, ELIEZER;HERZIG, YAACOV;LERNER, DAVID |