DELIVERY DEVICE CONTAINING VENLAFAXINE AND MEMANTINE AND USE METHOD THEREOF
摘要
The present invention provides an osmotic device containing controlled release venlafaxine in the core in combination with an anti-Alzheimer's or an anti-Parkinson's drug in a rapid release external coat. Memantine is used as an anti-Alzheimer's drug or an anti-Parkinson's drug. Particular embodiments of the invention provide osmotic devices having predetermined release profiles. One embodiment of the osmotic device includes an external coat that has been spray-coated rather than compression-coated onto the device. The device is useful for the treatment of depression in Alzheimer's and/or Parkinson's patients. The device and method can also be used to treat or ameliorate other symptoms associated with Alzheimer's disease, Parkinson's disease or any other neurological disorder. Other dosage forms that provide a controlled, sustained or extended release of venlafaxine in combination with a rapid or immediate release of memantine are useful in the invention.
申请公布号
WO2004056335(A2)
申请公布日期
2004.07.08
申请号
WO2003CR00004
申请日期
2003.12.19
申请人
OSMOTICA COSTA RICA SOCIEDAD ANONIMA;VERGEZ, JUAN, A.;FAOUR, JOAQUINA;RICCI, MARCELO, A.;PASTINI, ANA, C.
发明人
VERGEZ, JUAN, A.;FAOUR, JOAQUINA;RICCI, MARCELO, A.;PASTINI, ANA, C.