| 摘要 |
The present invention relates to tetrahydroquinoline derivatives having general formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1 and R2 are H or Me; R3 is H, hydroxy, (1-4C)alkoxy, (di)(1-4C)alkylamino(2- 4C)alkoxy or (2-6)heterocycloakl(2~-4C)alkoxy; R4 is H, OH, (1-4C)alkoxy or R7; R5 is H, OH, (1-4C)alkoxy or R7,with the proviso that if R4 is H, R5 is not H, OH or (1-4C)alkoxy and that if R5 is H, R4 is not H, OH or (1- 4C)alkoxy; R6 is (2-5C)heteroaryl, (6C)aryl, (3-8C)cycloalkyl, (2~ 6C)heterocycloalkyl or (1-6C)alkyl; R7 is amino, (di)(1-4C) alkylamino, (6C)arylcarbonylamino, (6C)arylcarbonyloxy, (2-5C) heteroarylcarbonylamino, (2~-5C)heteroarylcarbonyloxy, R8-(2-4C)alkylamino, R8-(2-4C)alkoxy, R9- methylamino or R9-methoxy; R8 is hydroxy, amino, (1-4C)alkoxy, (di)(1- 4C)alkylamino, (2-~6C)heterocycloalkyl, (2-6C) heterocycloalkylcarbonylamino , (di)(1-4C)alkylaminocarbonylamino, (1-4C) alkoxycarbonylamino and R9 is aminocarbonyl, (di)(1-4C)alkylaminocarbonyl, (2-5C)heteroaryl or (6C)aryl. T he present invention also relates to pharmaceutical compositions comprising sai d derivatives and the use of these derivatives to regulate fertility.
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