SUBSTITUTED ARYL- AND HETEROARYL-PHENYLOXAZOLIDINONES

摘要

The present invention discloses novel substituted aryl- and heteroarylphenyloxazolidinones which are useful as anti-bacterial agents. Compounds according to the invention have a structure as shown in Formula XII. (see formula I) More specifically, the substituted aryl- and heteroarylphenyloxazolidinones of the invention are characterized by oxazolidinones having an aryl or heteroaryl group at the p- position of the 3- phenyl ring and additional substitutions at the m-position(s) of the 3-pheny l ring. A compound representative of this new class of oxazolidinones is (~)-5-(acetamidomethyl )- 3-[4-(3-pyridyl)- 3,5-difluorophenyl]-2-oxazolidinone.