| 摘要 |
PROBLEM TO BE SOLVED: To provide an industrial method for efficiently producing an optically active 1-protected indoline-2-carboxylic acid derivative. SOLUTION: A racemic 1-protected indoline-2-carboxylic acid derivative is optically resolved with an optically active diamine or an optically active phenylalanineamide derivative. The optical resolver which can be desirably used is exemplified by optically active 1,2-diphenylethylenediamine, optically active 1,2-diaminocyclohexane, optically active phenylalaninemethylamide, optically active phenylalanineamide, optically active phenylalanine anilide, optically active phenylalanine-p-methoxyanilide, or optically active phenylalanine-p-chloroanilide. COPYRIGHT: (C)2004,JPO&NCIPI |
